Desabre, who coached the Cranes of Uganda at the 2019 Africa Cup of Nations (AFCON) in Egypt to the second round of the competition, was sacked after they lost the round of 16 match against Senegal last week.
He was officially unveiled as Pyramids FC coach on Monday, July 8, in Egypt.
This is the second job of the Frenchman in Egypt after a short spell with Ismaily SC in 2017, where he took charge of the club in 18 games.
During his time at Ismaily SC, won 13 games, drew four, while losing only once.
In their debut season, Pyramids FC have managed to finish second in the Egyptian Premier League, but could still drop to third in case Zamalek managed to win one of their remaining three games.