Patrick Osei-Wusu and Rexford Holland are being held by the police.
Mr William Amexo, Ashanti Regional Co-ordinator of the West African Examination Council (WAEC), told the Ghana News Agency that both suspects taught at the Chirapatre M/A/Junior High School (JHS) in Kumasi.
He said he was touring some examination centres in the metropolis with his deputy on Tuesday at about 0930 hours, when they noticed that some candidates at the Asem Boys Centre were having the same answers at the back of their question papers.
Upon questioning they mentioned Osei-Wusu as the one who dictated the answers to them.
Mr Amexo said the suspect initially profusely maintained his innocence but later confessed to engaging in the illegal act. He was subsequently handed over to the Zongo police for further investigation.
Holland was also caught on Wednesday during the Mathematics Paper One at the St Louis Demonstration JHS.
He had typed answers to the examination questions into his cellular phone and was transmitting to the candidates.
Mr Bampoe cautioned teachers and invigilators to desist from indulging in any act of cheating that could lead to their arrest and imprisonment.
A total of 78,348 candidates, made up of 41,110 males and 37,238 females are writing the BECE at 309 centres in the region.