Al-Qaeda leader Osama Bin Laden has been killed by US forces in Pakistan, President Barack Obama has said.
The al-Qaeda leader was killed in a ground operation outside Islamabad based on US intelligence, the first lead for which emerged last August.
Mr Obama said after “a firefight”, US forces took possession of his body.
Bin Laden was accused of being behind a number of atrocities, including the attacks on New York and Washington on 11 September 2001.
He was top of the US “most wanted” list.
Mr Obama said it was “the most significant achievement to date in our nation’s effort to defeat al-Qaeda”.
The US has put its embassies around the world on alert, warning Americans of the possibility of al-Qaeda reprisal attacks for Bin Laden’s killing.
Crowds gathered outside the White House in Washington DC, chanting “USA, USA” after the news emerged.
Bin Laden approved the 9/11 attacks in which nearly 3,000 people died, saying later that the results had exceeded his expectations.
He evaded the forces of the US and its allies for almost a decade, despite a $25m bounty on his head.
Mr Obama said he had been briefed last August on a possible lead to Bin Laden’s whereabouts.
“It was far from certain, and it took many months to run this thread to ground,” Mr Obama said.
“I met repeatedly with my national security team as we developed more information about the possibility that we had located Bin Laden hiding within a compound deep inside of Pakistan.
“And finally, last week, I determined that we had enough intelligence to take action, and authorised an operation to get Osama Bin Laden and bring him to justice,” the president said.
On Sunday a team of US forces undertook the operation in Abbottabad, 100km (62 miles) north-east of Islamabad.
After a “firefight” Bin Laden was killed and his body taken by US forces, the president said.
Mr Obama said “no Americans were harmed”.
Giving more details of the operation, a senior US official said a small US team had conducted the operation in about 40 minutes.
One helicopter was lost due to “technical failure”.
Three other men were also killed in the raid, including one of Bin Laden’s sons. One woman was killed when she was used as “a shield”, the official said.
The size and complexity of the structure in Abbottabad had “shocked” US officials.
It had 4m-6m (12ft-18ft) walls, was eight times larger than other homes in the area and was valued at “several million dollars”, though it had no telephone or internet connection.
The US official said that intelligence had been tracking a “trusted courier” of Bin Laden for many years. His identity was discovered four years ago, his area of operation two years ago and then, last August, his residence in Abbottabad was found, triggering the start of the operation.
Former US President George W Bush described the news as a “momentous achievement”.
“The fight against terror goes on, but tonight America has sent an unmistakable message: No matter how long it takes, justice will be done,” Mr Bush said in a statement.
His predecessor, Bill Clinton, said in a statement: “This is a profoundly important moment not just for the families of those who lost their lives on 9/11 and in al-Qaeda’s other attacks but for people all over the world who want to build a common future of peace, freedom, and cooperation for our children.”
BBC security correspondent Frank Gardner says that, to many in the West, Bin Laden became the embodiment of global terrorism, but to others he was a hero, a devout Muslim who fought two world superpowers in the name of jihad.
The son of a wealthy Saudi construction family, Bin Laden grew up in a privileged world. But soon after the Soviets invaded Afghanistan he joined the mujahideen there and fought alongside them with his Arab followers, a group that later formed the nucleus for al-Qaeda.
After declaring war on America in 1998, Bin Laden is widely believed to have been behind the bombings of US embassies in East Africa, the attack on the USS Cole in Yemen in 2000 and the attacks on New York and Washington.